EDNRA
EDNRA (Endothelin-1 receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer.
Overview
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, animal model 0.71, genetic association 0.00, clinical 0.85).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EDNRA (Endothelin-1 receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer.
- 1 · What it is
EDNRA (Endothelin-1 receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- 3 · How drugs use it
No product in this corpus aims at EDNRA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3179 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P25101 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000151617 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: prostate cancer 0.52 (GraphQL API, CC0))
Biology
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Location: Cell membrane (UniProt). Locus 4q31.22-q31.23 (HGNC).
- Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.85. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EDNRA" OR ABSTRACT:"EDNRA" OR TITLE:"endothelin receptor type A" OR ABSTRACT:"endothelin receptor type A" OR TITLE:"Endothelin-1 receptor" OR ABSTRACT:"Endothelin-1 receptor" OR TITLE:"ET-A" OR ABSTRACT:"ET-A" OR TITLE:"ETA-R" OR ABSTRACT:"ETA-R" OR TITLE:"hET-AR" OR ABSTRACT:"hET-AR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EDNRA, not a curated reading list.