EHBP1
EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.18, genetic association 0.61, genetic literature 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton.
- 3 · How drugs use it
No product in this corpus aims at EHBP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:29144 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NDI1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115504 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.54 (GraphQL API, CC0))
Biology
May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes. Location: Cytoplasm; Membrane; Endosome (UniProt). Locus 2p15 (HGNC).
- Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EHBP1" OR ABSTRACT:"EHBP1" OR TITLE:"EH domain binding protein 1" OR ABSTRACT:"EH domain binding protein 1" OR TITLE:"EH domain-binding protein 1" OR ABSTRACT:"EH domain-binding protein 1" OR TITLE:"KIAA0903" OR ABSTRACT:"KIAA0903" OR TITLE:"NACSIN" OR ABSTRACT:"NACSIN") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EHBP1, not a curated reading list.