ELP4
ELP4 (Elongator complex protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
Overview
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.37, animal model 0.57, genetic association 0.80).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ELP4 (Elongator complex protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
- 1 · What it is
ELP4 (Elongator complex protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
- 2 · What goes wrong in cancer
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
- 3 · How drugs use it
No product in this corpus aims at ELP4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1171 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96EB1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000109911 (association with cancer (MONDO_0004992) 0.51; per-cancer scores at or above 0.5: renal cell carcinoma 0.50 (GraphQL API, CC0))
Biology
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Location: Cytoplasm; Nucleus (UniProt). Locus 11p13 (HGNC).
- Renal cell carcinoma: Open Targets association 0.50 with renal cell carcinoma (MONDO_0005086)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ELP4" OR ABSTRACT:"ELP4" OR TITLE:"elongator acetyltransferase complex subunit 4" OR ABSTRACT:"elongator acetyltransferase complex subunit 4" OR TITLE:"Elongator complex protein 4" OR ABSTRACT:"Elongator complex protein 4" OR TITLE:"PAXNEB" OR ABSTRACT:"PAXNEB" OR TITLE:"C11orf19" OR ABSTRACT:"C11orf19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELP4, not a curated reading list.