EPHB3
EPHB3 (Ephrin type-B receptor 3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
Overview
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighboring cells. The signalling pathway downstream of the receptor is referred to as forward signalling while the signalling pathway downstream of the ephrin ligand is referred to as reverse signalling. Generally has an overlapping and redundant function with EPHB2.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.05, clinical 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EPHB3 (Ephrin type-B receptor 3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
- 1 · What it is
EPHB3 (Ephrin type-B receptor 3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.
- 2 · What goes wrong in cancer
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighboring cells.
- 3 · How drugs use it
No product in this corpus aims at EPHB3 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:3394 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P54753 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000182580 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: thyroid cancer 0.56, neuroendocrine neoplasm 0.54 (GraphQL API, CC0))
Biology
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighboring cells. The signalling pathway downstream of the receptor is referred to as forward signalling while the signalling pathway downstream of the ephrin ligand is referred to as reverse signalling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. Location: Cell membrane; Cell projection, dendrite (UniProt). Locus 3q27.1 (HGNC).
- Thyroid cancer: Open Targets association 0.56 with thyroid cancer (MONDO_0002108)
- Neuroendocrine tumours: Open Targets association 0.54 with neuroendocrine neoplasm (MONDO_0019496)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EPHB3" OR ABSTRACT:"EPHB3" OR TITLE:"EPH receptor B3" OR ABSTRACT:"EPH receptor B3" OR TITLE:"Ephrin type-B receptor 3" OR ABSTRACT:"Ephrin type-B receptor 3" OR TITLE:"Hek2" OR ABSTRACT:"Hek2" OR TITLE:"Tyro6" OR ABSTRACT:"Tyro6" OR TITLE:"ETK2" OR ABSTRACT:"ETK2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EPHB3, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetEPHA1
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
- TargetEPHA10
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
- TargetEPHA4
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
- TargetEPHA5
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
- TargetEPHA6
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
- TargetEPHA8
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
- TargetEPHB1
Shares Thyroid cancer, Neuroendocrine tumours, Open Targets Platform.
- TargetFOXE1
Shares Thyroid cancer, Open Targets Platform.