ERBIN
ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, genetic association 0.04, somatic mutation 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state.
- 3 · How drugs use it
No product in this corpus aims at ERBIN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:15842 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96RT1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000112851 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Biology
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion. Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes. Location: Cell junction, hemidesmosome; Nucleus membrane; Basolateral cell membrane; Cytoplasm (UniProt). Locus 5q12.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ERBIN" OR ABSTRACT:"ERBIN" OR TITLE:"erbb2 interacting protein" OR ABSTRACT:"erbb2 interacting protein" OR TITLE:"Erbin" OR ABSTRACT:"Erbin" OR TITLE:"LAP2" OR ABSTRACT:"LAP2" OR TITLE:"ERBB2IP" OR ABSTRACT:"ERBB2IP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERBIN, not a curated reading list.