ERCC1
ERCC1 (DNA excision repair protein ERCC-1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Mesothelioma, Ovarian cancer and 1 more.
Overview
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure.
CIViC holds 11 clinical evidence items and 0 assertions across 3 variants, naming Gemcitabine, Cisplatin, Platinum Compound and Paclitaxel and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ERCC1 (DNA excision repair protein ERCC-1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Mesothelioma, Ovarian cancer and 1 more.
- 1 · What it is
ERCC1 (DNA excision repair protein ERCC-1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Mesothelioma, Ovarian cancer and 1 more.
- 2 · What goes wrong in cancer
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL).
- 3 · How drugs use it
No product in this corpus aims at ERCC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3433 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P07992 (protein name, function text, keywords and locations (REST API)); CIViC gene ERCC1 (11 evidence items, 0 assertions, 3 variants; diseases: Lung Non-small Cell Carcinoma, Bladder Carcinoma, Malignant Pleural Mesothelioma, Epithelial Ovarian Cancer (GraphQL API, CC0))
Biology
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Not functional in the nucleotide excision repair pathway. Not functional in the nucleotide excision repair pathway. Location: Nucleus; Cytoplasm (UniProt). Locus 19q13.32 (HGNC).
- Bladder & urothelial cancer: CIViC evidence names this disease
- Mesothelioma: CIViC evidence names this disease
- Ovarian cancer: CIViC evidence names this disease
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 6 therapies; CIViC holds 11 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ERCC1" OR ABSTRACT:"ERCC1" OR TITLE:"ERCC excision repair 1, endonuclease non-catalytic subunit" OR ABSTRACT:"ERCC excision repair 1, endonuclease non-catalytic subunit" OR TITLE:"DNA excision repair protein ERCC-1" OR ABSTRACT:"DNA excision repair protein ERCC-1" OR TITLE:"RAD10" OR ABSTRACT:"RAD10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERCC1, not a curated reading list.
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