ERLIN2
ERLIN2 (Erlin-2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signalling pathway.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.95, genetic association 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ERLIN2 (Erlin-2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
ERLIN2 (Erlin-2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1.
- 3 · How drugs use it
No product in this corpus aims at ERLIN2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1356 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O94905 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147475 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Biology
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signalling pathway. May promote ER retention of the SCAP-SREBF complex. Location: Endoplasmic reticulum membrane (UniProt). Locus 8p11.23 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ERLIN2" OR ABSTRACT:"ERLIN2" OR TITLE:"ER lipid raft associated 2" OR ABSTRACT:"ER lipid raft associated 2" OR TITLE:"Erlin-2" OR ABSTRACT:"Erlin-2" OR TITLE:"NET32" OR ABSTRACT:"NET32" OR TITLE:"C8orf2" OR ABSTRACT:"C8orf2" OR TITLE:"SPFH2" OR ABSTRACT:"SPFH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERLIN2, not a curated reading list.