EZR
EZR (Ezrin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
Overview
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.99, animal model 0.50, genetic association 0.00, somatic mutation 0.91).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EZR (Ezrin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
- 1 · What it is
EZR (Ezrin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
- 2 · What goes wrong in cancer
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole.
- 3 · How drugs use it
No product in this corpus aims at EZR yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12691 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15311 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000092820 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: lung cancer 0.54 (GraphQL API, CC0))
Biology
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. Location: Apical cell membrane; Cell projection; Cell projection, microvillus membrane; Cell projection, ruffle membrane (UniProt). Locus 6q25.3 (HGNC).
- Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EZR" OR ABSTRACT:"EZR" OR TITLE:"ezrin" OR ABSTRACT:"ezrin" OR TITLE:"Ezrin" OR ABSTRACT:"Ezrin" OR TITLE:"VIL2" OR ABSTRACT:"VIL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EZR, not a curated reading list.