FANCB
FANCB (Fanconi anaemia group B protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Overview
DNA repair protein required for FANCD2 ubiquitination.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.72, genetic association 0.18, genetic literature 0.83).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FANCB (Fanconi anaemia group B protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 1 · What it is
FANCB (Fanconi anaemia group B protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
DNA repair protein required for FANCD2 ubiquitination. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FANCB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3583 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NB91 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000181544 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Biology
DNA repair protein required for FANCD2 ubiquitination. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FANCB" OR ABSTRACT:"FANCB" OR TITLE:"FA complementation group B" OR ABSTRACT:"FA complementation group B" OR TITLE:"Fanconi anemia group B protein" OR ABSTRACT:"Fanconi anemia group B protein" OR TITLE:"FLJ34064" OR ABSTRACT:"FLJ34064" OR TITLE:"FAAP95" OR ABSTRACT:"FAAP95") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FANCB, not a curated reading list.