FANCI
FANCI (Fanconi anaemia group I protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Overview
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.30, genetic association 0.50, genetic literature 0.83).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FANCI (Fanconi anaemia group I protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 1 · What it is
FANCI (Fanconi anaemia group I protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites.
- 3 · How drugs use it
No product in this corpus aims at FANCI yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:25568 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NVI1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140525 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage. Location: Nucleus; Cytoplasm (UniProt). Locus 15q26.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FANCI" OR ABSTRACT:"FANCI" OR TITLE:"FA complementation group I" OR ABSTRACT:"FA complementation group I" OR TITLE:"Fanconi anemia group I protein" OR ABSTRACT:"Fanconi anemia group I protein" OR TITLE:"FLJ10719" OR ABSTRACT:"FLJ10719" OR TITLE:"KIAA1794" OR ABSTRACT:"KIAA1794") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FANCI, not a curated reading list.