FANCM
FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.
Overview
DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes genetic literature 0.33, affected pathway 0.31, literature 0.67, genetic association 0.88, animal model 0.44).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.
- 1 · What it is
FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.
- 2 · What goes wrong in cancer
DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex.
- 3 · How drugs use it
No product in this corpus aims at FANCM yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:23168 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IYD8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000187790 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: ovarian cancer 0.53, breast cancer 0.55 (GraphQL API, CC0))
Biology
DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. Location: Nucleus (UniProt). Locus 14q21.2 (HGNC).
- Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.53 with ovarian cancer (MONDO_0008170)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FANCM" OR ABSTRACT:"FANCM" OR TITLE:"FA complementation group M" OR ABSTRACT:"FA complementation group M" OR TITLE:"Fanconi anemia group M protein" OR ABSTRACT:"Fanconi anemia group M protein" OR TITLE:"FAAP250" OR ABSTRACT:"FAAP250" OR TITLE:"KIAA1596" OR ABSTRACT:"KIAA1596") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FANCM, not a curated reading list.