FGF3
FGF3 (Fibroblast growth factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Hepatocellular carcinoma.
Overview
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Sorafenib and Dovitinib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.49, affected pathway 0.92, animal model 0.25, genetic association 0.13).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FGF3 (Fibroblast growth factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Hepatocellular carcinoma.
- 1 · What it is
FGF3 (Fibroblast growth factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Hepatocellular carcinoma.
- 2 · What goes wrong in cancer
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.
- 3 · How drugs use it
No product in this corpus aims at FGF3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3681 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11487 (protein name, function text, keywords and locations (REST API)); CIViC gene FGF3 (3 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer, Hepatocellular Carcinoma, Cancer (GraphQL API, CC0)); Open Targets ENSG00000186895 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
Biology
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. Location: Secreted (UniProt). Locus 11q13.3 (HGNC).
- Breast cancer: CIViC evidence names this disease
- Hepatocellular carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FGF3" OR ABSTRACT:"FGF3" OR TITLE:"fibroblast growth factor 3" OR ABSTRACT:"fibroblast growth factor 3" OR TITLE:"Fibroblast growth factor 3" OR ABSTRACT:"Fibroblast growth factor 3" OR TITLE:"HBGF-3" OR ABSTRACT:"HBGF-3" OR TITLE:"INT2" OR ABSTRACT:"INT2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF3, not a curated reading list.