FGF4
FGF4 (Fibroblast growth factor 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Overview
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells.
CIViC holds 4 clinical evidence items and 0 assertions across 2 variants, naming Sorafenib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.40, affected pathway 0.94, genetic association 0.05).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FGF4 (Fibroblast growth factor 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
- 1 · What it is
FGF4 (Fibroblast growth factor 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
- 2 · What goes wrong in cancer
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
- 3 · How drugs use it
No product in this corpus aims at FGF4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3682 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08620 (protein name, function text, keywords and locations (REST API)); CIViC gene FGF4 (4 evidence items, 0 assertions, 2 variants; diseases: Cancer, Hepatocellular Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000075388 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
Biology
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells. Location: Secreted (UniProt). Locus 11q13.3 (HGNC).
- Hepatocellular carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FGF4" OR ABSTRACT:"FGF4" OR TITLE:"fibroblast growth factor 4" OR ABSTRACT:"fibroblast growth factor 4" OR TITLE:"Fibroblast growth factor 4" OR ABSTRACT:"Fibroblast growth factor 4" OR TITLE:"K-FGF" OR ABSTRACT:"K-FGF" OR TITLE:"HBGF-4" OR ABSTRACT:"HBGF-4" OR TITLE:"HST-1" OR ABSTRACT:"HST-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF4, not a curated reading list.