FGF8
FGF8 (Fibroblast growth factor 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.98, animal model 0.30, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FGF8 (Fibroblast growth factor 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
FGF8 (Fibroblast growth factor 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis.
- 3 · How drugs use it
No product in this corpus aims at FGF8 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3686 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P55075 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107831 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Biology
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Location: Secreted (UniProt). Locus 10q24.32 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FGF8" OR ABSTRACT:"FGF8" OR TITLE:"fibroblast growth factor 8" OR ABSTRACT:"fibroblast growth factor 8" OR TITLE:"Fibroblast growth factor 8" OR ABSTRACT:"Fibroblast growth factor 8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF8, not a curated reading list.