FOXC2
FOXC2 (Forkhead box protein C2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Overview
Transcriptional activator.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Oxaliplatin.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FOXC2 (Forkhead box protein C2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 1 · What it is
FOXC2 (Forkhead box protein C2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Transcriptional activator. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FOXC2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:3801 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99958 (protein name, function text, keywords and locations (REST API)); CIViC gene FOXC2 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Biology
Transcriptional activator. Location: Nucleus (UniProt). Locus 16q24.1 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FOXC2" OR ABSTRACT:"FOXC2" OR TITLE:"forkhead box C2" OR ABSTRACT:"forkhead box C2" OR TITLE:"Forkhead box protein C2" OR ABSTRACT:"Forkhead box protein C2" OR TITLE:"MFH-1" OR ABSTRACT:"MFH-1" OR TITLE:"FKHL14" OR ABSTRACT:"FKHL14") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXC2, not a curated reading list.