FOXP4
FOXP4 (Forkhead box protein P4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Transcriptional repressor that represses lung-specific expression.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.98, animal model 0.43, genetic association 0.61, somatic mutation 0.28).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FOXP4 (Forkhead box protein P4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
FOXP4 (Forkhead box protein P4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Transcriptional repressor that represses lung-specific expression. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FOXP4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:20842 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IVH2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137166 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
Transcriptional repressor that represses lung-specific expression. Location: Nucleus (UniProt). Locus 6p21.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FOXP4" OR ABSTRACT:"FOXP4" OR TITLE:"forkhead box P4" OR ABSTRACT:"forkhead box P4" OR TITLE:"Forkhead box protein P4" OR ABSTRACT:"Forkhead box protein P4" OR TITLE:"FLJ40908" OR ABSTRACT:"FLJ40908") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXP4, not a curated reading list.