FRK kinase
FRK is a SRC-related kinase that mostly acts as a brake on growth; it is a minor off-target of approved kinase inhibitors and is lost or mutated in some liver and brain cancers.
Overview
Fyn-related kinase (FRK) is a non-receptor tyrosine kinase of the SRC family that, unusually for the family, behaves as a tumour suppressor in several tissues: it stabilises PTEN, and its loss is reported in glioma, hepatocellular carcinoma and breast cancer. It is listed as a target of approved drugs because multi-kinase inhibitors such as dasatinib bind it, rather than because inhibiting it is the goal. Activating FRK fusions and mutations have been described in a minority of liver cancers, where kinase inhibition may be relevant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FRK is a SRC-related kinase that mostly acts as a brake on growth; it is a minor off-target of approved kinase inhibitors and is lost or mutated in some liver and brain cancers.
- 1 · What it is
FRK is a SRC-related kinase that mostly acts as a brake on growth; it is a minor off-target of approved kinase inhibitors and is lost or mutated in some liver and brain cancers.
- 2 · What goes wrong in cancer
A nuclear and cytoplasmic SRC-family kinase expressed in epithelial tissues, brain and liver; it phosphorylates PTEN and retinoblastoma protein, slowing the cell cycle.
- 3 · How drugs use it
No product in this corpus aims at FRK kinase yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Biology
A nuclear and cytoplasmic SRC-family kinase expressed in epithelial tissues, brain and liver; it phosphorylates PTEN and retinoblastoma protein, slowing the cell cycle.
- Epithelial tissues, brain and liver
- Reduced in glioma, hepatocellular carcinoma and some breast cancers
Latest papers
topQuery for this target: (TITLE:"FRK kinase" OR ABSTRACT:"FRK kinase" OR TITLE:"FRK" OR ABSTRACT:"FRK") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FRK kinase, not a curated reading list.
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