LYN kinase
LYN is a SRC-family kinase that sits under the B-cell receptor; dasatinib and bosutinib inhibit it alongside BCR-ABL, and LYN over-activity is one way chronic myeloid leukaemia escapes imatinib.
Overview
LYN is a SRC-family tyrosine kinase expressed in B cells and myeloid cells, where it both amplifies and restrains signalling from the B-cell receptor and cytokine receptors. In chronic myeloid leukaemia, over-expression of LYN is a recognised mechanism of imatinib resistance that does not involve a BCR-ABL mutation, and the second-generation inhibitors dasatinib and bosutinib block LYN and other SRC kinases directly. LYN is also constitutively active in chronic lymphocytic leukaemia cells, contributing to their survival.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LYN is a SRC-family kinase that sits under the B-cell receptor; dasatinib and bosutinib inhibit it alongside BCR-ABL, and LYN over-activity is one way chronic myeloid leukaemia escapes imatinib.
- 1 · What it is
LYN is a SRC-family kinase that sits under the B-cell receptor; dasatinib and bosutinib inhibit it alongside BCR-ABL, and LYN over-activity is one way chronic myeloid leukaemia escapes imatinib.
- 2 · What goes wrong in cancer
A membrane-anchored non-receptor tyrosine kinase; it phosphorylates immunoreceptor tyrosine motifs to start SYK signalling and also activates inhibitory phosphatases, giving it dual roles.
- 3 · How drugs use it
No product in this corpus aims at LYN kinase yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Biology
A membrane-anchored non-receptor tyrosine kinase; it phosphorylates immunoreceptor tyrosine motifs to start SYK signalling and also activates inhibitory phosphatases, giving it dual roles.
- B lymphocytes and myeloid cells
- Imatinib-resistant CML and CLL cells
Latest papers
topQuery for this target: (TITLE:"LYN kinase" OR ABSTRACT:"LYN kinase" OR TITLE:"LYN" OR ABSTRACT:"LYN") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LYN kinase, not a curated reading list.
Similar pages
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