FRS3
FRS3 (Fibroblast growth factor receptor substrate 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signalling by interfering with the phosphorylation and nuclear translocation of ERK2.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.76, genetic association 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FRS3 (Fibroblast growth factor receptor substrate 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
FRS3 (Fibroblast growth factor receptor substrate 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases.
- 3 · How drugs use it
No product in this corpus aims at FRS3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:16970 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43559 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137218 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signalling by interfering with the phosphorylation and nuclear translocation of ERK2. Location: Membrane (UniProt). Locus 6p21.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FRS3" OR ABSTRACT:"FRS3" OR TITLE:"fibroblast growth factor receptor substrate 3" OR ABSTRACT:"fibroblast growth factor receptor substrate 3" OR TITLE:"Fibroblast growth factor receptor substrate 3" OR ABSTRACT:"Fibroblast growth factor receptor substrate 3" OR TITLE:"SNT-2" OR ABSTRACT:"SNT-2" OR TITLE:"FRS2beta" OR ABSTRACT:"FRS2beta" OR TITLE:"FRS2B" OR ABSTRACT:"FRS2B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FRS3, not a curated reading list.