GAS6
GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Overview
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Docetaxel.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 1 · What it is
GAS6 (Growth arrest-specific protein 6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration.
- 3 · How drugs use it
No product in this corpus aims at GAS6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4168 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14393 (protein name, function text, keywords and locations (REST API)); CIViC gene GAS6 (2 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer, Oral Squamous Cell Carcinoma (GraphQL API, CC0))
Biology
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signalling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signalling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signalling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry. Location: Secreted (UniProt). Locus 13q34 (HGNC).
- Prostate cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Oral Squamous Cell Carcinoma.
Latest papers
topQuery for this target: (TITLE:"GAS6" OR ABSTRACT:"GAS6" OR TITLE:"growth arrest specific 6" OR ABSTRACT:"growth arrest specific 6" OR TITLE:"Growth arrest-specific protein 6" OR ABSTRACT:"Growth arrest-specific protein 6" OR TITLE:"FLJ34709" OR ABSTRACT:"FLJ34709" OR TITLE:"DKFZp666G247" OR ABSTRACT:"DKFZp666G247" OR TITLE:"AXLLG" OR ABSTRACT:"AXLLG") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GAS6, not a curated reading list.