GDF7
GDF7 (Growth/differentiation factor 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
May play an active role in the motor area of the primate neocortex.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.67, animal model 0.71, genetic association 0.80).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GDF7 (Growth/differentiation factor 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
GDF7 (Growth/differentiation factor 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May play an active role in the motor area of the primate neocortex. Location: Secreted (UniProt).
- 3 · How drugs use it
No product in this corpus aims at GDF7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4222 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z4P5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143869 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
May play an active role in the motor area of the primate neocortex. Location: Secreted (UniProt). Locus 2p24.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GDF7" OR ABSTRACT:"GDF7" OR TITLE:"growth differentiation factor 7" OR ABSTRACT:"growth differentiation factor 7" OR TITLE:"Growth/differentiation factor 7" OR ABSTRACT:"Growth/differentiation factor 7" OR TITLE:"BMP12" OR ABSTRACT:"BMP12") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GDF7, not a curated reading list.