GOLGA4
GOLGA4 (Golgin subfamily A member 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.68, affected pathway 0.76, genetic association 0.38).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GOLGA4 (Golgin subfamily A member 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
GOLGA4 (Golgin subfamily A member 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.
- 3 · How drugs use it
No product in this corpus aims at GOLGA4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4427 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13439 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000144674 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Biology
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking. Location: Cytoplasm; Golgi apparatus membrane; Golgi apparatus, trans-Golgi network membrane (UniProt). Locus 3p22.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GOLGA4" OR ABSTRACT:"GOLGA4" OR TITLE:"golgin A4" OR ABSTRACT:"golgin A4" OR TITLE:"Golgin subfamily A member 4" OR ABSTRACT:"Golgin subfamily A member 4" OR TITLE:"golgin-245" OR ABSTRACT:"golgin-245" OR TITLE:"GCP2" OR ABSTRACT:"GCP2" OR TITLE:"p230" OR ABSTRACT:"p230") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GOLGA4, not a curated reading list.