GOLGA5
GOLGA5 (Golgin subfamily A member 5) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.10, genetic association 0.00, somatic mutation 0.92).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GOLGA5 (Golgin subfamily A member 5) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
GOLGA5 (Golgin subfamily A member 5) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons.
- 3 · How drugs use it
No product in this corpus aims at GOLGA5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4428 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8TBA6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000066455 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. Location: Golgi apparatus membrane (UniProt). Locus 14q32.12 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GOLGA5" OR ABSTRACT:"GOLGA5" OR TITLE:"golgin A5" OR ABSTRACT:"golgin A5" OR TITLE:"Golgin subfamily A member 5" OR ABSTRACT:"Golgin subfamily A member 5" OR TITLE:"ret-II" OR ABSTRACT:"ret-II" OR TITLE:"golgin-84" OR ABSTRACT:"golgin-84" OR TITLE:"rfg5" OR ABSTRACT:"rfg5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GOLGA5, not a curated reading list.