HERPUD1
HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.56, somatic mutation 0.68).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.
- 3 · How drugs use it
No product in this corpus aims at HERPUD1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:13744 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15011 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000051108 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. Location: Endoplasmic reticulum membrane (UniProt). Locus 16q13 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HERPUD1" OR ABSTRACT:"HERPUD1" OR TITLE:"homocysteine inducible ER protein with ubiquitin like domain 1" OR ABSTRACT:"homocysteine inducible ER protein with ubiquitin like domain 1" OR TITLE:"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein" OR ABSTRACT:"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein" OR TITLE:"KIAA0025" OR ABSTRACT:"KIAA0025" OR TITLE:"Mif1" OR ABSTRACT:"Mif1" OR TITLE:"HERPUD1-IT1" OR ABSTRACT:"HERPUD1-IT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HERPUD1, not a curated reading list.