HHIP
HHIP (Hedgehog-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.96, animal model 0.40, genetic association 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HHIP (Hedgehog-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
HHIP (Hedgehog-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Location: Cell membrane; Secreted; Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at HHIP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:14866 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96QV1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164161 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.52 (GraphQL API, CC0))
Biology
Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Location: Cell membrane; Secreted; Cytoplasm (UniProt). Locus 4q31.21 (HGNC).
- Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HHIP" OR ABSTRACT:"HHIP" OR TITLE:"hedgehog interacting protein" OR ABSTRACT:"hedgehog interacting protein" OR TITLE:"Hedgehog-interacting protein" OR ABSTRACT:"Hedgehog-interacting protein" OR TITLE:"FLJ20992" OR ABSTRACT:"FLJ20992") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HHIP, not a curated reading list.