HNF1B
HNF1B (Hepatocyte nuclear factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma and Ovarian cancer.
Overview
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.92, affected pathway 0.35, literature 0.98, genetic association 0.88, animal model 0.25).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HNF1B (Hepatocyte nuclear factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma and Ovarian cancer.
- 1 · What it is
HNF1B (Hepatocyte nuclear factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma and Ovarian cancer.
- 2 · What goes wrong in cancer
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene.
- 3 · How drugs use it
No product in this corpus aims at HNF1B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:11630 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35680 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000275410 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: renal cell carcinoma 0.71, ovarian cancer 0.54 (GraphQL API, CC0))
Biology
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1. Location: Nucleus (UniProt). Locus 17q12 (HGNC).
- Renal cell carcinoma: Open Targets association 0.71 with renal cell carcinoma (MONDO_0005086)
- Ovarian cancer: Open Targets association 0.54 with ovarian cancer (MONDO_0008170)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HNF1B" OR ABSTRACT:"HNF1B" OR TITLE:"HNF1 homeobox B" OR ABSTRACT:"HNF1 homeobox B" OR TITLE:"Hepatocyte nuclear factor 1-beta" OR ABSTRACT:"Hepatocyte nuclear factor 1-beta" OR TITLE:"LFB3" OR ABSTRACT:"LFB3" OR TITLE:"VHNF1" OR ABSTRACT:"VHNF1" OR TITLE:"HNF1beta" OR ABSTRACT:"HNF1beta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HNF1B, not a curated reading list.