HNF4G
HNF4G (Hepatocyte nuclear factor 4-gamma) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.63).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HNF4G (Hepatocyte nuclear factor 4-gamma) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
HNF4G (Hepatocyte nuclear factor 4-gamma) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
- 3 · How drugs use it
No product in this corpus aims at HNF4G yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:5026 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14541 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164749 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Transcription factor. Has a lower transcription activation potential than HNF4-alpha. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HNF4G" OR ABSTRACT:"HNF4G" OR TITLE:"hepatocyte nuclear factor 4 gamma" OR ABSTRACT:"hepatocyte nuclear factor 4 gamma" OR TITLE:"Hepatocyte nuclear factor 4-gamma" OR ABSTRACT:"Hepatocyte nuclear factor 4-gamma" OR TITLE:"NR2A2" OR ABSTRACT:"NR2A2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HNF4G, not a curated reading list.