HNRNPH1
HNRNPH1 (Heterogeneous nuclear ribonucleoprotein H) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
Overview
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HNRNPH1 (Heterogeneous nuclear ribonucleoprotein H) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
- 1 · What it is
HNRNPH1 (Heterogeneous nuclear ribonucleoprotein H) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
- 2 · What goes wrong in cancer
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm.
- 3 · How drugs use it
No product in this corpus aims at HNRNPH1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:5041 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31943 (protein name, function text, keywords and locations (REST API)); CIViC gene HNRNPH1 (2 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma (GraphQL API, CC0))
Biology
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Location: Nucleus, nucleoplasm (UniProt). Locus 5q35.3 (HGNC).
- Mantle cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HNRNPH1" OR ABSTRACT:"HNRNPH1" OR TITLE:"heterogeneous nuclear ribonucleoprotein H1" OR ABSTRACT:"heterogeneous nuclear ribonucleoprotein H1" OR TITLE:"Heterogeneous nuclear ribonucleoprotein H" OR ABSTRACT:"Heterogeneous nuclear ribonucleoprotein H" OR TITLE:"hnRNPH" OR ABSTRACT:"hnRNPH" OR TITLE:"HNRPH1" OR ABSTRACT:"HNRPH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HNRNPH1, not a curated reading list.
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