HSP90B1
HSP90B1 (Endoplasmin) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Temozolomide and Onalespib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HSP90B1 (Endoplasmin) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
HSP90B1 (Endoplasmin) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport.
- 3 · How drugs use it
No product in this corpus aims at HSP90B1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:12028 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P14625 (protein name, function text, keywords and locations (REST API)); CIViC gene HSP90B1 (1 evidence items, 0 assertions, 1 variants; diseases: Glioma (GraphQL API, CC0))
Biology
ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors. Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10. Location: Endoplasmic reticulum lumen; Sarcoplasmic reticulum lumen; Melanosome (UniProt). Locus 12q23.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glioma.
Latest papers
topQuery for this target: (TITLE:"HSP90B1" OR ABSTRACT:"HSP90B1" OR TITLE:"heat shock protein 90 beta family member 1" OR ABSTRACT:"heat shock protein 90 beta family member 1" OR TITLE:"Endoplasmin" OR ABSTRACT:"Endoplasmin" OR TITLE:"GP96" OR ABSTRACT:"GP96" OR TITLE:"GRP94" OR ABSTRACT:"GRP94" OR TITLE:"TRA1" OR ABSTRACT:"TRA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSP90B1, not a curated reading list.