INCENP
INCENP (Inner centromere protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Acts as a scaffold regulating CPC localisation and activity.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.50, genetic association 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · INCENP (Inner centromere protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
INCENP (Inner centromere protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
- 3 · How drugs use it
No product in this corpus aims at INCENP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6058 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NQS7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000149503 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Acts as a scaffold regulating CPC localisation and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB and AURKC. Location: Nucleus; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle; Midbody (UniProt). Locus 11q12.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"INCENP" OR ABSTRACT:"INCENP" OR TITLE:"inner centromere protein" OR ABSTRACT:"inner centromere protein" OR TITLE:"Inner centromere protein" OR ABSTRACT:"Inner centromere protein" OR TITLE:"FLJ31633" OR ABSTRACT:"FLJ31633") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about INCENP, not a curated reading list.