ITPKB
ITPKB (Inositol-trisphosphate 3-kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Overview
Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ITPKB (Inositol-trisphosphate 3-kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 1 · What it is
ITPKB (Inositol-trisphosphate 3-kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 2 · What goes wrong in cancer
Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
- 3 · How drugs use it
No product in this corpus aims at ITPKB yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:6179 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P27987 (protein name, function text, keywords and locations (REST API)); CIViC gene ITPKB (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Biology
Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. Location: Cytoplasm, cytoskeleton; Cytoplasm; Endoplasmic reticulum (UniProt). Locus 1q42.12 (HGNC).
- Diffuse large B-cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ITPKB" OR ABSTRACT:"ITPKB" OR TITLE:"inositol-trisphosphate 3-kinase B" OR ABSTRACT:"inositol-trisphosphate 3-kinase B" OR TITLE:"Inositol-trisphosphate 3-kinase B" OR ABSTRACT:"Inositol-trisphosphate 3-kinase B" OR TITLE:"IP3KB" OR ABSTRACT:"IP3KB" OR TITLE:"IP3-3KB" OR ABSTRACT:"IP3-3KB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ITPKB, not a curated reading list.