KCNA3
KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.47, clinical 0.76).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Mediates the voltage-dependent potassium ion permeability of excitable membranes.
- 3 · How drugs use it
No product in this corpus aims at KCNA3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6221 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P22001 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000177272 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Biology
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Lacks voltage-gated potassium channel activity. Location: Cell membrane; Cytoplasm, perinuclear region (UniProt). Locus 1p13.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KCNA3" OR ABSTRACT:"KCNA3" OR TITLE:"potassium voltage-gated channel subfamily A member 3" OR ABSTRACT:"potassium voltage-gated channel subfamily A member 3" OR TITLE:"Potassium voltage-gated channel subfamily A member 3" OR ABSTRACT:"Potassium voltage-gated channel subfamily A member 3" OR TITLE:"Kv1.3" OR ABSTRACT:"Kv1.3" OR TITLE:"MK3" OR ABSTRACT:"MK3" OR TITLE:"HLK3" OR ABSTRACT:"HLK3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KCNA3, not a curated reading list.