KCNH8
KCNH8 (Voltage-gated delayed rectifier potassium channel KCNH8) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.12, animal model 0.45, genetic association 0.49, clinical 0.76).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KCNH8 (Voltage-gated delayed rectifier potassium channel KCNH8) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
KCNH8 (Voltage-gated delayed rectifier potassium channel KCNH8) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents.
- 3 · How drugs use it
No product in this corpus aims at KCNH8 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:18864 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96L42 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000183960 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials. Activation is strongly dependent on the pH of the external solution. Location: Membrane (UniProt). Locus 3p24.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KCNH8" OR ABSTRACT:"KCNH8" OR TITLE:"potassium voltage-gated channel subfamily H member 8" OR ABSTRACT:"potassium voltage-gated channel subfamily H member 8" OR TITLE:"Voltage-gated delayed rectifier potassium channel KCNH8" OR ABSTRACT:"Voltage-gated delayed rectifier potassium channel KCNH8" OR TITLE:"Kv12.1" OR ABSTRACT:"Kv12.1" OR TITLE:"elk3" OR ABSTRACT:"elk3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KCNH8, not a curated reading list.