KIAA1549
KIAA1549 (UPF0606 protein KIAA1549) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
May play a role in photoreceptor function.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.25, affected pathway 0.89, genetic association 0.00, somatic mutation 0.50).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KIAA1549 (UPF0606 protein KIAA1549) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
KIAA1549 (UPF0606 protein KIAA1549) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May play a role in photoreceptor function. Location: Membrane; Cell projection, cilium (UniProt).
- 3 · How drugs use it
No product in this corpus aims at KIAA1549 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:22219 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HCM3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000122778 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
May play a role in photoreceptor function. Location: Membrane; Cell projection, cilium (UniProt). Locus 7q34 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KIAA1549" OR ABSTRACT:"KIAA1549" OR TITLE:"UPF0606 protein KIAA1549" OR ABSTRACT:"UPF0606 protein KIAA1549") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KIAA1549, not a curated reading list.