KLC1
KLC1 (Kinesin light chain 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.76, genetic association 0.38).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KLC1 (Kinesin light chain 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
KLC1 (Kinesin light chain 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
- 3 · How drugs use it
No product in this corpus aims at KLC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6387 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q07866 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126214 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Location: Cell projection, growth cone; Cytoplasmic vesicle; Cytoplasm, cytoskeleton (UniProt). Locus 14q32.33 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KLC1" OR ABSTRACT:"KLC1" OR TITLE:"kinesin light chain 1" OR ABSTRACT:"kinesin light chain 1" OR TITLE:"Kinesin light chain 1" OR ABSTRACT:"Kinesin light chain 1" OR TITLE:"KNS2A" OR ABSTRACT:"KNS2A" OR TITLE:"hKLC1S" OR ABSTRACT:"hKLC1S" OR TITLE:"hKLC1N" OR ABSTRACT:"hKLC1N") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLC1, not a curated reading list.