KLHDC8B
KLHDC8B (Kelch domain-containing protein 8B) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Hodgkin lymphoma.
Overview
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KLHDC8B (Kelch domain-containing protein 8B) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Hodgkin lymphoma.
- 1 · What it is
KLHDC8B (Kelch domain-containing protein 8B) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Hodgkin lymphoma.
- 2 · What goes wrong in cancer
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability.
- 3 · How drugs use it
No product in this corpus aims at KLHDC8B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:28557 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IXV7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000185909 (per-cancer scores at or above 0.5: Hodgkins lymphoma 0.55 (GraphQL API, CC0))
Biology
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. Location: Cytoplasm; Midbody (UniProt). Locus 3p21.31 (HGNC).
- Hodgkin lymphoma: Open Targets association 0.55 with Hodgkins lymphoma (MONDO_0004952)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KLHDC8B" OR ABSTRACT:"KLHDC8B" OR TITLE:"kelch domain containing 8B" OR ABSTRACT:"kelch domain containing 8B" OR TITLE:"Kelch domain-containing protein 8B" OR ABSTRACT:"Kelch domain-containing protein 8B" OR TITLE:"MGC35097" OR ABSTRACT:"MGC35097") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLHDC8B, not a curated reading list.
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