KLHL14
KLHL14 (Kelch-like protein 14) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Overview
UniProt has no function text for Q9P2G3; HGNC names it "kelch like family member 14".
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KLHL14 (Kelch-like protein 14) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 1 · What it is
KLHL14 (Kelch-like protein 14) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 2 · What goes wrong in cancer
UniProt has no function text for Q9P2G3; HGNC names it "kelch like family member 14". Location: Cytoplasm, cytosol; Endoplasmic reticulum membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at KLHL14 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:29266 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9P2G3 (protein name, function text, keywords and locations (REST API)); CIViC gene KLHL14 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Biology
UniProt has no function text for Q9P2G3; HGNC names it "kelch like family member 14". Location: Cytoplasm, cytosol; Endoplasmic reticulum membrane (UniProt). Locus 18q12.1 (HGNC).
- Diffuse large B-cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KLHL14" OR ABSTRACT:"KLHL14" OR TITLE:"kelch like family member 14" OR ABSTRACT:"kelch like family member 14" OR TITLE:"Kelch-like protein 14" OR ABSTRACT:"Kelch-like protein 14" OR TITLE:"KIAA1384" OR ABSTRACT:"KIAA1384") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLHL14, not a curated reading list.