KLK3
KLK3 (Prostate-specific antigen) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Overview
Hydrolyses semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 1.00, genetic association 0.74, clinical 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KLK3 (Prostate-specific antigen) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 1 · What it is
KLK3 (Prostate-specific antigen) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Hydrolyses semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Location: Secreted (UniProt).
- 3 · How drugs use it
No product in this corpus aims at KLK3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:6364 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P07288 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000142515 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: prostate cancer 0.67 (GraphQL API, CC0))
Biology
Hydrolyses semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Location: Secreted (UniProt). Locus 19q13.33 (HGNC).
- Prostate cancer: Open Targets association 0.67 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.61. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KLK3" OR ABSTRACT:"KLK3" OR TITLE:"kallikrein related peptidase 3" OR ABSTRACT:"kallikrein related peptidase 3" OR TITLE:"Prostate-specific antigen" OR ABSTRACT:"Prostate-specific antigen") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLK3, not a curated reading list.
Similar pages
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