NKX3-1
NKX3-1 (Homeobox protein Nkx-3.1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumour suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.96, animal model 0.88, genetic association 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NKX3-1 (Homeobox protein Nkx-3.1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
NKX3-1 (Homeobox protein Nkx-3.1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor.
- 3 · How drugs use it
No product in this corpus aims at NKX3-1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7838 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99801 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167034 (association with cancer (MONDO_0004992) 0.50; per-cancer scores at or above 0.5: prostate cancer 0.50 (GraphQL API, CC0))
Biology
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumour suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Location: Nucleus (UniProt). Locus 8p21.2 (HGNC).
- Prostate cancer: Open Targets association 0.50 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NKX3-1" OR ABSTRACT:"NKX3-1" OR TITLE:"NK3 homeobox 1" OR ABSTRACT:"NK3 homeobox 1" OR TITLE:"Homeobox protein Nkx-3.1" OR ABSTRACT:"Homeobox protein Nkx-3.1" OR TITLE:"NKX3.1" OR ABSTRACT:"NKX3.1" OR TITLE:"BAPX2" OR ABSTRACT:"BAPX2" OR TITLE:"NKX3A" OR ABSTRACT:"NKX3A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NKX3-1, not a curated reading list.
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