LAMC1
LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.96, animal model 0.44, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components.
- 3 · How drugs use it
No product in this corpus aims at LAMC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6492 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11047 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135862 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway. Location: Secreted, extracellular space, extracellular matrix, basement membrane (UniProt). Locus 1q25.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LAMC1" OR ABSTRACT:"LAMC1" OR TITLE:"laminin subunit gamma 1" OR ABSTRACT:"laminin subunit gamma 1" OR TITLE:"Laminin subunit gamma-1" OR ABSTRACT:"Laminin subunit gamma-1" OR TITLE:"LAMB2" OR ABSTRACT:"LAMB2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LAMC1, not a curated reading list.