LMO1
LMO1 (Rhombotin-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.37, somatic mutation 0.96).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LMO1 (Rhombotin-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
LMO1 (Rhombotin-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at LMO1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6641 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P25800 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166407 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.51 (GraphQL API, CC0))
Biology
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Location: Nucleus (UniProt). Locus 11p15.4 (HGNC).
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LMO1" OR ABSTRACT:"LMO1" OR TITLE:"LIM domain only 1" OR ABSTRACT:"LIM domain only 1" OR TITLE:"Rhombotin-1" OR ABSTRACT:"Rhombotin-1" OR TITLE:"TTG1" OR ABSTRACT:"TTG1" OR TITLE:"RHOM1" OR ABSTRACT:"RHOM1" OR TITLE:"RBTN1" OR ABSTRACT:"RBTN1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LMO1, not a curated reading list.