LMO2
LMO2 (Rhombotin-2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
Overview
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes affected pathway 0.35, literature 0.93, genetic association 0.03, somatic mutation 0.96, animal model 0.52).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LMO2 (Rhombotin-2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 1 · What it is
LMO2 (Rhombotin-2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
- 3 · How drugs use it
No product in this corpus aims at LMO2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6642 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P25791 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135363 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0))
Biology
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. Location: Nucleus (UniProt). Locus 11p13 (HGNC).
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LMO2" OR ABSTRACT:"LMO2" OR TITLE:"LIM domain only 2" OR ABSTRACT:"LIM domain only 2" OR TITLE:"Rhombotin-2" OR ABSTRACT:"Rhombotin-2" OR TITLE:"TTG2" OR ABSTRACT:"TTG2" OR TITLE:"RHOM2" OR ABSTRACT:"RHOM2" OR TITLE:"RBTN2" OR ABSTRACT:"RBTN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LMO2, not a curated reading list.