LMX1B
LMX1B (LIM homeobox transcription factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.80, animal model 0.69, genetic association 0.62).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LMX1B (LIM homeobox transcription factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
LMX1B (LIM homeobox transcription factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
- 3 · How drugs use it
No product in this corpus aims at LMX1B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:6654 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60663 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136944 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Location: Nucleus (UniProt). Locus 9q33.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LMX1B" OR ABSTRACT:"LMX1B" OR TITLE:"LIM homeobox transcription factor 1 beta" OR ABSTRACT:"LIM homeobox transcription factor 1 beta" OR TITLE:"LIM homeobox transcription factor 1-beta" OR ABSTRACT:"LIM homeobox transcription factor 1-beta" OR TITLE:"NPS1" OR ABSTRACT:"NPS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LMX1B, not a curated reading list.