LRFN2
LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.81, animal model 0.55, genetic association 0.65).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A.
- 3 · How drugs use it
No product in this corpus aims at LRFN2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:21226 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9ULH4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156564 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery. Location: Membrane; Synapse; Postsynaptic cell membrane (UniProt). Locus 6p21.2-p21.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LRFN2" OR ABSTRACT:"LRFN2" OR TITLE:"leucine rich repeat and fibronectin type III domain containing 2" OR ABSTRACT:"leucine rich repeat and fibronectin type III domain containing 2" OR TITLE:"Leucine-rich repeat and fibronectin type-III domain-containing protein 2" OR ABSTRACT:"Leucine-rich repeat and fibronectin type-III domain-containing protein 2" OR TITLE:"FIGLER2" OR ABSTRACT:"FIGLER2" OR TITLE:"KIAA1246" OR ABSTRACT:"KIAA1246" OR TITLE:"SALM1" OR ABSTRACT:"SALM1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LRFN2, not a curated reading list.