MAP3K13
MAP3K13 (Mitogen-activated protein kinase kinase kinase 13) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Lung cancer and 1 more.
Overview
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MAP3K13 (Mitogen-activated protein kinase kinase kinase 13) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Lung cancer and 1 more.
- 1 · What it is
MAP3K13 (Mitogen-activated protein kinase kinase kinase 13) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Lung cancer and 1 more.
- 2 · What goes wrong in cancer
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol.
- 3 · How drugs use it
No product in this corpus aims at MAP3K13 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:6852 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43283 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000073803 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.55, breast cancer 0.53, lung cancer 0.51 (GraphQL API, CC0))
Biology
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. Location: Cytoplasm; Membrane (UniProt). Locus 3q27.2 (HGNC).
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MAP3K13" OR ABSTRACT:"MAP3K13" OR TITLE:"mitogen-activated protein kinase kinase kinase 13" OR ABSTRACT:"mitogen-activated protein kinase kinase kinase 13" OR TITLE:"Mitogen-activated protein kinase kinase kinase 13" OR ABSTRACT:"Mitogen-activated protein kinase kinase kinase 13" OR TITLE:"MEKK13" OR ABSTRACT:"MEKK13") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAP3K13, not a curated reading list.
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