MCL1
MCL1 (Induced myeloid leukaemia cell differentiation protein Mcl-1) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma.
Overview
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Mcl-1 Inhibitor MIK665. In OnCo, 1 product record names it (Omacetaxine mepesuccinate).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MCL1 (Induced myeloid leukaemia cell differentiation protein Mcl-1) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma.
- 1 · What it is
MCL1 (Induced myeloid leukaemia cell differentiation protein Mcl-1) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma.
- 2 · What goes wrong in cancer
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
- 3 · How drugs use it
No product in this corpus aims at MCL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6943 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q07820 (protein name, function text, keywords and locations (REST API)); CIViC gene MCL1 (1 evidence items, 0 assertions, 1 variants; diseases: Multiple Myeloma (GraphQL API, CC0))
Biology
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. Location: Membrane; Cytoplasm; Mitochondrion; Nucleus, nucleoplasm (UniProt). Locus 1q21.2 (HGNC).
- Multiple myeloma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MCL1" OR ABSTRACT:"MCL1" OR TITLE:"MCL1 apoptosis regulator, BCL2 family member" OR ABSTRACT:"MCL1 apoptosis regulator, BCL2 family member" OR TITLE:"Induced myeloid leukemia cell differentiation protein Mcl-1" OR ABSTRACT:"Induced myeloid leukemia cell differentiation protein Mcl-1" OR TITLE:"BCL2L3" OR ABSTRACT:"BCL2L3" OR TITLE:"Mcl-1" OR ABSTRACT:"Mcl-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MCL1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetASCL1
- TargetCDK9
- TargetMYC
Shares mRNA translation (eIF4F / mTOR), Transcriptional machinery & addiction, CIViC, Multiple myeloma.
- TargetEP300
- TargetIRF4
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- TargetIKZF3 (Aiolos)
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- TargetIKZF1 (Ikaros)
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- PathwayAcute myeloid leukaemia (KEGG map)
Shares Intrinsic apoptosis (BCL-2 family), Transcriptional machinery & addiction.