CDK9
CDK9 (Cyclin-dependent kinase 9) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Oesophageal cancer and Neuroblastoma.
Overview
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Dinaciclib, Alvocidib and CAN508.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CDK9 (Cyclin-dependent kinase 9) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Oesophageal cancer and Neuroblastoma.
- 1 · What it is
CDK9 (Cyclin-dependent kinase 9) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Oesophageal cancer and Neuroblastoma.
- 2 · What goes wrong in cancer
Protein kinase involved in the regulation of transcription.
- 3 · How drugs use it
No product in this corpus aims at CDK9 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:1780 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P50750 (protein name, function text, keywords and locations (REST API)); CIViC gene CDK9 (3 evidence items, 0 assertions, 1 variants; diseases: Neuroblastoma, Hepatocellular Carcinoma, Oesophageal Cancer (GraphQL API, CC0))
Biology
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signalling). Location: Nucleus; Cytoplasm; Nucleus, PML body (UniProt). Locus 9q34.11 (HGNC).
- Hepatocellular carcinoma: CIViC evidence names this disease
- Oesophageal cancer: CIViC evidence names this disease
- Neuroblastoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CDK9" OR ABSTRACT:"CDK9" OR TITLE:"cyclin dependent kinase 9" OR ABSTRACT:"cyclin dependent kinase 9" OR TITLE:"Cyclin-dependent kinase 9" OR ABSTRACT:"Cyclin-dependent kinase 9" OR TITLE:"PITALRE" OR ABSTRACT:"PITALRE" OR TITLE:"C-2k" OR ABSTRACT:"C-2k" OR TITLE:"CDC2L4" OR ABSTRACT:"CDC2L4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDK9, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetAURKA
Shares MYC, Oesophageal cancer, CIViC.
- TargetPCNA
Shares Neuroblastoma (paediatric), CIViC.
- TargetPLK1
- TargetASCL1
- CompanyCaptor Therapeutics
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.
- TargetEP300
Shares Transcriptional machinery & addiction, Oesophageal cancer, CIViC.
- TargetMYO5A
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.
- TargetPRDM2
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.