MIR21
MIR21 (microRNA 21) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Overview
UniProt has no function text for this gene; HGNC names it "microRNA 21".
CIViC holds 4 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MIR21 (microRNA 21) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
- 1 · What it is
MIR21 (microRNA 21) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
UniProt has no function text for this gene; HGNC names it "microRNA 21". Locus 17q23.1 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at MIR21 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:31586 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); CIViC gene MIR21 (4 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma, Malignant Astrocytoma, Glioma (GraphQL API, CC0))
Biology
UniProt has no function text for this gene; HGNC names it "microRNA 21". Locus 17q23.1 (HGNC).
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Malignant Astrocytoma; Glioma.
Latest papers
topQuery for this target: (TITLE:"MIR21" OR ABSTRACT:"MIR21" OR TITLE:"microRNA 21" OR ABSTRACT:"microRNA 21" OR TITLE:"hsa-mir-21" OR ABSTRACT:"hsa-mir-21" OR TITLE:"MIR-21" OR ABSTRACT:"MIR-21" OR TITLE:"MIRN21" OR ABSTRACT:"MIRN21") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MIR21, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetMYC
Shares MicroRNAs in cancer, CIViC.