MLF1
MLF1 (Myeloid leukaemia factor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer.
Overview
Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.49, genetic association 0.00, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MLF1 (Myeloid leukaemia factor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer.
- 1 · What it is
MLF1 (Myeloid leukaemia factor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer.
- 2 · What goes wrong in cancer
Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation.
- 3 · How drugs use it
No product in this corpus aims at MLF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7125 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P58340 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178053 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: lung cancer 0.52 (GraphQL API, CC0))
Biology
Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. Location: Cytoplasm; Nucleus; Cell projection, cilium; Cytoplasm, cytoskeleton, cilium basal body (UniProt). Locus 3q25.32 (HGNC).
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MLF1" OR ABSTRACT:"MLF1" OR TITLE:"myeloid leukemia factor 1" OR ABSTRACT:"myeloid leukemia factor 1" OR TITLE:"Myeloid leukemia factor 1" OR ABSTRACT:"Myeloid leukemia factor 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MLF1, not a curated reading list.