MSR1
MSR1 (Macrophage scavenger receptor types I and II) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognises and internalises modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidised LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.73, genetic literature 0.30).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MSR1 (Macrophage scavenger receptor types I and II) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
MSR1 (Macrophage scavenger receptor types I and II) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.
- 3 · How drugs use it
No product in this corpus aims at MSR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7376 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P21757 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000038945 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Biology
Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognises and internalises modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidised LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense. Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signalling. Does not internalise acetylated LDL. Location: Cell membrane (UniProt). Locus 8p22 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MSR1" OR ABSTRACT:"MSR1" OR TITLE:"macrophage scavenger receptor 1" OR ABSTRACT:"macrophage scavenger receptor 1" OR TITLE:"Macrophage scavenger receptor types I and II" OR ABSTRACT:"Macrophage scavenger receptor types I and II" OR TITLE:"SCARA1" OR ABSTRACT:"SCARA1" OR TITLE:"CD204" OR ABSTRACT:"CD204" OR TITLE:"SR-AI" OR ABSTRACT:"SR-AI") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MSR1, not a curated reading list.